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In participants receiving apitegromab, trough concentrations of apitegromab and total latent myostatin, a pharmacodynamic marker, both increased over time and reached a plateau after approximately 16 weeks

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doi:10.1371/journal.pone.0068331

Most published research and the commercially available research-grade material is supplied as the copper-bound complex, which is the biologically active form in published cell-culture and animal studies

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